✅ What is DES(1-3) IGF-1?
DES(1-3) IGF-1 is a modified, more potent version of IGF-1 (Insulin-like Growth Factor-1). It’s a synthetic peptide where the first three amino acids of regular IGF-1 have been removed. This alteration significantly increases its biological activity.
💡 Key Characteristics
- Length: 67 amino acids (like IGF-1, but missing the first 3).
- Enhanced potency: 5 to 10 times more powerful than standard IGF-1.
- Lower affinity to IGF-binding proteins, which allows it to act more freely.
- Very short half-life: Around 20–30 minutes.
💪 Common (Non-medical) Uses in Bodybuilding
- Stimulates muscle hypertrophy (muscle growth).
- Promotes muscle cell repair and regeneration.
- May enhance nutrient uptake at the cellular level.
- Often injected locally into the muscle for targeted growth.
📊 Comparison: IGF-1 vs DES(1-3) IGF-1
| Feature | IGF-1 (Standard) | DES(1-3) IGF-1 |
|---|---|---|
| Potency | Moderate | High (5–10x more potent) |
| Half-life | Longer (~20 hours) | Short (~20–30 mins) |
| Localized effect | Minimal | Strong localized action |
| Binding to IGF proteins | Strong | Weak |
⚠️ Risks and Side Effects
Use of DES(1-3) IGF-1, especially outside clinical settings, carries risks:
- Hypoglycemia (low blood sugar).
- Abnormal tissue growth.
- Headaches, dizziness.
- Insulin resistance.
- Potential cancer risks (as it promotes cell proliferation).
- Not FDA-approved for bodybuilding or anti-aging use.
💉 Typical Usage (for informational purposes only)
⚠️ Not medical advice. For educational purposes only.
- Dosage: 10–50 mcg per day.
- Route: Subcutaneous or intramuscular injection.
- Timing: Often post-workout to support muscle recovery and growth.
🧠 Summary
DES(1-3) IGF-1 is a highly active peptide with strong muscle-building effects, especially when used locally. While its effectiveness is well-known in performance circles, it comes with considerable risks and should only be considered with caution—and ideally under medical supervision
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